A team of scientists at the Garvan Institute of Medical Research, Sydney has announced two breakthrough studies with respect to pancreatic cancer treatment within a single week.
A team of scientists from the Garvan Institute of Medical Research in Sydney has come up with hope for the treatment of cancer with the help of two breakthrough studies within a single week. The breakthrough studies can help in slowing the overall growth as well as the spread of pancreatic cancer in the body. The researchers during the study revealed that by reducing the levels of “perclean” –a specific molecule, can help in reducing the overall spread of pancreatic cancer in the body. The study was conducted in an animal model and served to deliver an improved response to conventional chemotherapy treatment.
New Study Reducing Spread and Boosting Drug Therapy
In pancreatic cancer, the quick spread of the disease serves to be the main cause of cancer-related deaths. The early stages of the diseases have no symptoms, and later diagnosis of the same tends to lead to the average survival rate of just three and a half months. In addition to this, chemotherapy is not effective on pancreatic cancer as most of the tumors are protected by some hard shell-like covering.
In the study, the researchers have found that some of the pancreatic cancer tumors are known to produce more levels of perclean in comparison to others. This allows cancer to spread more easily. Perclean is also known to protect the tumor against chemotherapy. The study follows a two-pronged approach for the treatment of pancreatic cancer that aims at improving the efficiency of chemotherapy and can thus, help in reducing tumor progression as well as its spread.
The Study Involving Fibroblasts
The scientists made use of animal models for extracting fibroblasts –cells producing matrix (tissues around the pancreatic cancer cells), from spreading as well as from non-spreading pancreatic tumors. The researchers found that cancer cells from the non-spreading pancreatic cancer started spreading when they were mixed with fibroblasts from another spreading pancreatic tumor. This implies that in a spreading tumor, the presence of even a small number of metastatic cells can increase the spread of other cancer cells.
In yet another breakthrough study, a team of scientists at the University of Texas revealed that FMT (Fecal microbiota transplants) from the long-term pancreatic cancer survivors accelerated immune response and stifled the pancreatic cancer tumors in mice samples.