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The Prognostic Importance of Antigen 45 (CT45) in Extending Life of an Ovarian Cancer Patient

Patients who are living through a High-Grade Serious Ovarian cancer may have greater chances of survival after this new treatment through immunotherapy and Chemotherapy. A cancer antigen named as 45 (CT45), which has been identified during a proteomic analysis. These antigens are regarded as promising targets for tumor therapy. Patients with a higher level of [...]

Patients who are living through a High-Grade Serious Ovarian cancer may have greater chances of survival after this new treatment through immunotherapy and Chemotherapy.

A cancer antigen named as 45 (CT45), which has been identified during a proteomic analysis. These antigens are regarded as promising targets for tumor therapy. Patients with a higher level of antigen show that they may survive for a longer time.

Authors of Max Plank Institute in Germany studied about this and they claim that one among six patients with Ovarian Cancer lives disease free in the next ten years. These are the patients being treated with surgery and carboplatin/paclitaxel Chemotherapy. 80% among these have to seek Chemotherapy frequently. There haven’t been any molecular mechanisms identified for patients who survive and those who don’t.

Investigators made an analysis and published the results. Here paraffin embedded patient samples were studied. Among them, 11 HGSOC chemoresistant patients (median DFS, 190 days) and 14 chemosensitive patients (DFS, 1, 160 days).

Researchers studied almost 90,000 protein samples and came to know that patients with high CT45 expression depicted a better chance of survival and along this had a median DFS of 2,745 days as compared to 366 days in rest of the patients. They could have been living for 2,903 days while other patients had 1,078 survival days. The study was repeatedly confirmed.

Marion Curtis from the University of Chicago said that tumors response to carboplatin which is due to  CT45. CT45 and PP4 phosphate complex interact, and this connects CT45 to DNA damage pathways.

Finally, the research creates a hope for us that if CT45 is activated in a tumor, it could help in a more effective treatment for cancer by carboplatin.

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