Results from a new study have revealed that the compounds that responsible for creating the heat in the chili peppers can actually help in slowing down the progression of lung cancer. Lung cancer is one of the major reasons for deaths due to cancer in men & women all around the world. Most of the deaths related to cancer occur due to the spreading of cancer to distant organs or sites –the process is referred to as “metastasis.”
Jamie Friedman –a doctoral candidate who performed the research at the laboratory at Mashall University Joan C. Edwards School of Medicine, states, “Lung cancer along with other types of cancers usually tends to metastasize to other secondary locations including liver, bone, or the brain. As such, this condition makes it difficult to treat cancer in most cases. Our recent study suggests that the presence of the natural heating compound ‘capsaicin’ in the chili peppers can help in representing a novel therapy for combating metastasis in patients with lung cancer.”
Study on Chili Peppers
Friedman is known to represent the results of the research at the annual meeting of the American Society for Investigative Pathology during the 2019 meeting of Experimental Biology.
In the respective clinical experiments that involved as many as three lines non-small cell human lung cancer cells that were cultured, the team of researchers observed that capsaicin was responsible for inhibiting invasion –the initial step of the process of metastasis. The researchers also observed that mice having metastatic cancer and having consumed chili pepper revealed smaller areas of cancer in the lung in comparison to the mice which did not receive the chili peppers.
Role of Capsaicin in Suppressing Lung Cancer
Another set of experiments performed by the researchers revealed that capsaicin in chili peppers also helped in suppressing the process of metastasis during lung cancer. This was achieved by the inhibition of the activation of the specific protein “Src.” The Src protein is known to be responsible for signaling the controlling of the fundamental cellular processes including motility, adhesion, proliferation, and differentiation.