Often times, science has discovered something cool yet useful by accident. The same has happened at the University of British Columbia lately when the scientists were observing the blood vessel damage in mice. The scientists were studying the impact of a specific enzyme known as “Granzyme B” on blood vessel aging. However, they came up with something bizarre after completing their investigation. The mice lacking Granzyme B had sleek skin in comparison to the normal mice that were aging at a faster rate. Does this study claim that preventing this enzyme could keep the human’s skin young and wrinkle-free?
Apart from being an enzyme, Granzyme B is particularly a serine protease. This signifies that Granzyme B enzyme has the potential to break down other proteins. Being created and released by Cytotoxic T-cells and NK cells, Granzyme B performs an array of functions in the human body. However, its secretion by immune cells causes are often linked to ECM breakdown.
Extracellular Matrix (ECM) is the group of proteins combined with molecules which specifically functions by filling up the gap between cells. In order to confirm the theory, the researchers conducted the same experiment on other mice lacking Granzyme B. The mice were put out in the sun for many times a week together with the other group of mice that had the average Granzyme B expression. The weird results showed that mice belonging to the control group were spotted with wrinkles and skin aging symptoms. On the other hand, the skin of the other mice group wasn’t affected at all.
According to the researchers, the main reason why Granzyme B causes skin aging effects is due to its function in the ECM. It interrupts the structural reliability of collagen – one of the major structural proteins in your body. As soon as the ECM loses collagen, human skin tends to show up wrinkles. When your skin is exposed to the UV rays for a long time, its cells are infected with the virus or produces pre-cancerous skin changes. As a result, the collagen of the ECM damages. If there is any way to get rid of premature aging, one has to clearly eliminate the Granzyme B from their blood vessels. However, as Granzyme B is an important element for your immune cells, it can’t be eliminated completely.
The best thing researchers suggest is to use natural and synthetic inhibitors after exposing your skin to UV rays. It can avoid the unnecessary breakdown of collagen and thus, won’t affect your skin cells.
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