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Scientists Discovered a Drug Target for Neurodegenerative Diseases & Cancer

A medical research team based in Bhubaneswar, India has discovered the downregulation of a protein named “TRIM16” could help in the treatment of neurodegenerative diseases and cancer. In the hope for coming across a potential treatment for cancer and other neurodegenerative diseases in the coming future, this observation can set a benchmark in the pretext [...]

A medical research team based in Bhubaneswar, India has discovered the downregulation of a protein named “TRIM16” could help in the treatment of neurodegenerative diseases and cancer. In the hope for coming across a potential treatment for cancer and other neurodegenerative diseases in the coming future, this observation can set a benchmark in the pretext of the same.

The team of researchers at the Institute of Life Sciences, Bhubaneswar has found that the activation of a specific type of protein named TRIM16 can serve to be a potential therapeutic strategy for the treatment of a wide array of neurodegenerative diseases including ALS (amyotrophic lateral sclerosis), Alzheimer’s disease, and Parkinsons’s disease. In addition to this, the inhibition of the specific protein in the cancer cells could help in bringing about a reduction in the proliferation of tumor. The results of the study were published in THE EMBO Journal.

The study by the medical team that was carried out in lab mice and test tubes has revealed that the particular protein TRIM16 has the ability to protect the cancer cells from oxidative stress. As such, the inhibition of this protein could lead to the reduced amount of tumor growth in the body.

Potential Treatment for Neurodegenerative Diseases

The team of medical researchers supervised by Santosh Chauhan found that the TRIM16 protein played a vital role in both the formation of protein aggregates, as well as in their successive degradation. When more of TRIM16 protein gets produced by activation, the process of the degradation of the unwanted material (autophagy) gets boosted. Thus, it leads to an increased rate of protein aggregate degradation.

Given the potential of the study towards combating the growth of tumor cells and helping in dealing with neurodegenerative diseases, there is a great hope for the future of cancer treatment.

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