Constant hard work had been continued by researchers to increase the age limit for the patients suffering from bowel cancer. The basic aim was to increase the number of survivors and to create a ray of hope in patients all over the globe.
Finally, the researchers got what they were looking for!
Late Chancellor of Queen’s University Belfast through Tom Moran Scholarship aided a project which aimed to invent a therapy for bowel cancer patients, improving their lives and increasing their chances of survival. It had never been done before.
A research project was established where two groups of patients were formed. The focus was to find out how a bunch of cells respond to stress. Gene signatures were determined and this kind of response was called as Unfolded Protein Response. Then this response was thought to treat bowel cancer. In a study it was confirmed, that an end UPR pathway aids a cell to fight with stress period. It was also seen that highly stressed cancer cells used the UPR for survival. There was a need to be wise now. Apoptosis is the self-death of cells which was the need here. Dr. Forsythe gave an idea that cancer cells can also be stressed by combining some drugs in a specific proportion and survival for cancer cells would come to an end. It was apoptosis.
The Braf gene was the leader both in treating cancer and causing cancer. It contained a protein called as B-Raf which could help in signal transmission from the cell surface which is the basic agenda for survival. Similarly, mutations cause cancer and B-Raf mutants are not easy to be diagnosed by conventional methods.
Finally, researchers at Queen’s University discovered a cellular process to kill cancer cells by keeping in view the aggressive nature of cancer cells. Research is still being carried out to bring up chances for survival of more and more people suffering from bowel cancer and colorectal tumors. Drugs are being designed for better survival of cancer patients.