A recent study reveals that specific bacteria on tumors can help in impacting the overall tumor response as well as the survival of the patients having pancreatic cancer.
A recent study by a team of researchers at the University of Texas MD Anderson Cancer Center has revealed that certain bacteria on tumor can help in influencing the response of the immune system while impacting the survival of the patients with pancreatic cancer. The study also reveals that the primary difference between patients who tend to survive for long and others who are not able to do so, is the respective bacteria signature on the tumors that can either suppress or stimulate the immune response of the body. The results of the study were published in the journal “Cell.”
The Study Analyzing the Behavior of Bacteria on Tumor
The team of researchers also analyzed that FMT (Fecal microbiota transplants) from the long-term cancer survivors can help in prompting the immune response while stifling tumors in a given mouse sample of pancreatic cancer. This was achieved by altering the bacteria on the given tumor –the microbiome.
Florencia McAllister –MD & Assistant Professor at MD Anderson in the Department of Clinical Cancer Prevention, states that the results of the experiments involving FMT tend to feature a significant opportunity in the pretext of improving treatment for pancreatic cancer by altering the immune microenvironment of the tumor. While this appears promising, the scientists are still expected to work even further in the given scenario.
The Results of the Study
The process of immune profiling revealed that mice receiving the FMT samples from the long-term cancer survivors appeared to have higher numbers as well as improved activation of the respective CD8-positive T-cells in comparison to those who did not receive the same. The mice samples receiving the FMT from patients with an advanced stage of pancreatic cancer witnessed an increase in T cells communities along with myeloid-derived suppressor cells –both are responsible for suppressing the immune system of the body.
For evaluating whether or not FMT relies on the body’s immune system, the team of researchers deprived the T cells in a specific group of mice samples that were given treatment with FMT received from long-term pancreatic cancer survivors. This helped in completely blocking the anti-tumor effect of the given transplant.