Acute Myeloid Leukemia (AML) is one of the most aggressive forms of cancers, harming bone marrow and causing it to produce abnormal myeloblasts. Little innovation has arrived regarding its treatments, given its variety and amount of proteins causing cancerous cells to rapidly multiply and preventing them from chemotherapy treatments. However, researchers from the Hebrew University of Jerusalem might have come up with a dose of hope.
The researchers have established a new biological drug which acts as a cluster bomb. The molecule has been developed by manipulating a cancer cell chemically which succeeds in attacking multiple leukemic proteins in a go, taking away leukemic cells’ ability to activate more proteins in order to escape or evade given therapy. It destroys oncogenes as well as activates P53 (a tumor suppressor gene).
Mice injected with acute leukemia showed 50 percent of cure rate. The drug portrayed dramatic changes right after a single dose. According to the researchers, almost all the signs of leukemia vanished overnight in the mice. There were mice with leukemia as well as those injected with human leukemia. Researchers claim that the drug worked on even the most aggressive type of human leukemia.
AML has been treated with chemotherapy and stem cell injections so far. This new drug comes in a pill form. It can cover the work of 3-4 other drugs which enables the patients to avoid additional therapies and their intense side effects.
The phase 1 clinical study of this drug is hoped to be started at the start of 2019. The drug is projected to take 2-3 years before it can be commercialized. Researchers are now working on how to extend the use of this drug for other types of cancers like melanoma, lymphoma, colorectal and multiple myeloma cancers.