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Metabolomics Could Lead to Better Cancer Prevention and Treatment

Keeping track of our metabolism is necessary to know what risks our body can be going through. Most importantly, the amount of fat we consume. According to various researchers, there is a major correlation between cancer and excessive fat intake since the 1930s. Today, obesity stands second to tobacco as a major cause of cancers [...]

Keeping track of our metabolism is necessary to know what risks our body can be going through. Most importantly, the amount of fat we consume. According to various researchers, there is a major correlation between cancer and excessive fat intake since the 1930s. Today, obesity stands second to tobacco as a major cause of cancers that can be prevented otherwise in the UK. It is expected that the risk of cancer due to obesity would cross the risks put forward by tobacco in the coming future.

The reason fat poses such a threat is because it produces certain hormones that can signal the growth of cells and immune function. There is an increased risk of the Metabolic syndrome which includes chronic conditions like hyperglycemia and insulin resistance, which in turn leads to more growth factors (for example, Insulin Growth Factor, IGF-1). These growth factors lead to more division and growth of cells, which is really harmful if the cells are cancerous. Additionally, fat has pro-inflammatory factors, therefore, obese cancer patients are treated with paracetamol and aspirin along with chemotherapy. Fat increases the risk of breast cancer in post-menopausal women and men because it produces unnecessary estrogen hormone.

To lower these risk factors, it is much needed to track our diet, for which, metabolomics is very beneficial. Metabolomics is the study of biomarkers that represent nutritional status and various metabolic states in the human body. Using the very technique and similar technology, researchers have made out a specific metabolic profile that can predict the risk of cancer two to five years prior to its chance of occurring with the help of a mammogram.

Metabolomics is an objective approach to studying data regarding the effects of nutrition on cancer risks. It can help target the chemicals that we can utilize to fight against cancer. Cancer cells can mutate and change their cellular diet, consisting more of glucose, glutamate, serine and glycine. The scientists also found that limiting the presence of amino acid asparagine can stop metastasis of cancer in animal models. These discoveries can pave way for a patient-specific diet plan that can complement corresponding traditional therapy.

Hence, keeping track of our diet is a must because we are what we eat.

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