A new study performed by a team of researchers in Italy might serve as a breakthrough in achieving the effective delivery of the drugs used for the treatment of Mesothelioma. In the study, results that were published in the latest Journal named “Journal of Nanomedicine,” the scientists were able to identify a specific target on the malignant pleural mesothelioma cells & its surface. After this, the scientists managed to program the gold nanoparticles that were loaded with a chemotherapy drug to seek the respective targets out. By doing this, the scientists found out that the all-new system of drug delivery was substantially more effective than the process of administering the chemotherapy drug alone. The gold nanoparticles were taken up selectively within 1 hour of delivery. The nanoparticles were also successful in blocking the cell lines from replication and causing an impact on both cell ability and viability to advance. The scientists were also able to find that cell death had increased significantly by the utilization of the gold nanoparticles.
Researchers in Italy Explore the Utilization of the Revolutionary Drug Delivery System
The team of researchers in Italy from the Clinic of Lung Diseases wrote on the challenges presented by malignant mesothelioma for the overall treatment. The Research Center of Regenerative Medicine states about the toxic side effects that the current delivery of chemotherapy imposes on the patient’s body. This, in turn, prevents increased dosage as demanded by the recalcitrant tumors of the disease. The search by the group of researchers for the presence of a novel drug delivery strategy led the team to come across the theory of gold nanoparticles. As per the scientists, the gold nanoparticles tend to have unique size-dependent optical as well as electronic properties, biocompatibility, and chances of customization.
The previous work of the group with gold nanoparticles enabled them to believe that it could serve as an effective therapeutic option for the treatment of mesothelioma. Therefore, the team of researchers also identified a protein “CD146” – expressed by the diseases as a specific target that serves suitable for nanoparticle functionalization. The scientists loaded the nanoparticles with pemetrexed after which the treatment for mesothelioma began in the lab. During the study, the scientists studied that impact of the nanoparticles on the cell uptake, cell death, cell viability, cell cycle, colony-forming capacity, wound healing, and reactive oxygen species.
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