Lesser Risk of Kidney Cancer with more Vitamin D Binding Protein


A study conducted for the second time establishes that with more vitamin D binding protein circulation, there is a lesser risk of developing kidney cancer. The related findings are in correspondence with the previous results that also demonstrated the inverse relationship between Vitamin D binding protein and risk of kidney cancer, specifically Renal Cell Carcinoma, RCC.

The current study has been conducted since 1992, initiated in the American Cancer Society Cancer Prevention Study-II (CPS-II) Nutrition Cohort, involving 39,371 people who submitted their blood sample, with no presence of cancer prior to submission. Prior to June 30, 2009, it was observed that 87 out of these people went through a primary diagnosis of RCC. The data related to diagnosis was assimilated by means of self-reported questionnaires, medical records’ reviews and NDI (the National Death Index).

The results revealed that a higher level of serum DPB concentration led to a lowered risk of RCC. Those participants who had higher levels of DPB were younger, mostly females, non-smokers and had a lower BMI (body mass index).

According to Dr. Alison Mondul, an assistant professor of epidemiology at the University of Michigan and the author of this study, it has been revealed that risk of developing kidney cancer is not caused by vitamin D itself, however, to estimate the presence of free vitamin D versus that which is bound in circulation seems important as other molecular structures like hormones in our body can have an effect on us if they are free. However, free Vitamin D was also found to be not associated with the development of renal cell carcinoma. These associations are positive in colorectal cancer, prostate cancer, lung cancer and bladder cancer, however, for renal sites, the case of vitamin D’s effect differs and it requires more research.

DPB has been found to influence cancer formation in this case, outside of its general role of transporting Vitamin D metabolites to various sites in our bodies. The statistical power of the study is meager because of the rarity of RCC cases. Further studies will be conducted in the non-white population as kidney cancer incidence occurs more in black men in the United States than white men.