When studied for the cure for cancer, the ketogenic diet has shown remarkable results when tested on mice. A ketogenic diet is a low-carb, moderate-protein, and high-fat diet which subjects the body into a metabolic state referred to as “ketosis”. However, is it really the cure for the deadly disease? A study recently published in Nature has revealed how the combination of a ketogenic diet could help in curing a specific type of cancer. The diet has shown a remarkable response to the particular type of cancer drug known as the “PI3K” inhibitor which has been successful in improving the overall effects of the cancer drug in mice samples.
The researchers and their teams made use of the mouse models to reveal the effects of the ketogenic diet on different types of cancers. The study was aimed at showing the effects of glucose & insulin towards blocking the results of PI3K inhibitors. By introducing the mice to a ketogenic diet for lowering the blood glucose or nursing with the drug named as a SGLT2 inhibitor (preventing the reabsorption of glucose by the kidneys) made the effects of the drug highly productive in reducing the cancer growth in mice.
A highly known side effect of the PI3K inhibitor drug is the increased insulin levels and high blood sugar. The side effect normally tends to pass away. However, in can be prolonged in the patients suffering from insulin resistance –in cases of diabetes. In such a case, the therapy gets discontinued as insulin stimulates PI3K resulting in the formation of tumors & accelerating cancer growth.
PI3Ks are the family of enzymes that are involved in the regulation of the metabolism of the cell glucose. As such, these are vital towards controlling the cell function. The PI3K mutations that affect the process are found in a wide range of cancers and are common in a major proportion of the famous cancers.