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FR900359, Discovered from Plants to Reduces Tumor Growth in Melanoma

Research to control cancer and to fight with it has been continued for years. Deadly Eye cancer has frequently seen in people. There is a pigmented layer of cells in the iris of the eye which causes the Ocular Melanoma. The tumor arises from the pigmented cells that reside in Uvea giving color to the [...]

Research to control cancer and to fight with it has been continued for years. Deadly Eye cancer has frequently seen in people. There is a pigmented layer of cells in the iris of the eye which causes the Ocular Melanoma. The tumor arises from the pigmented cells that reside in Uvea giving color to the eye. These melanocytes are different from retinal cells which do not cause eye cancer. It causes 3 to 5% of life loss.

Cancerous cell growth in melanoma is due to overactive signaling. G alpha q is present in cancer of the eye and to make the best use of it to cure cancer, researchers at Washington University School of Medicine in St. Louis discovered a natural plant compound called FR900359. This compound belongs to the primrose family of plants. The goal is to shut down the entire signaling cascade in melanoma, which can be made possible in presence of a drug which suddenly captures G alpha q in its inactive state.

This prevents partial turning off for the cascade activated by G alpha q.

Senior author Kendall J.Bulmer who is a professor of cell biology and physiology states that FR traps cancer-causing fork of G alpha and captures it when it is in an inactive form.

There is no need to turn off cancer-causing form of G alpha because this happens naturally and that is the point where FR traps it.

In this way, tumor growth is controlled and diminished.

FR kills melanoma cells and also reverts to another class of cells present in an eye that are similar to normally pigmented cells of the eye.

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