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An Innovation to Save Lives

Viruses are non-living biological entities that remain dormant outside the host. They only replicate themselves when they are present inside the body of the host. Similarly, Epstein Bar Virus (EBV) and Kaposi’s Sarcoma Herpes Virus (KSHV) keep themselves safe from being destroyed. Adam Cheng studied about these viruses and stated that in some cases they [...]

Viruses are non-living biological entities that remain dormant outside the host. They only replicate themselves when they are present inside the body of the host. Similarly, Epstein Bar Virus (EBV) and Kaposi’s Sarcoma Herpes Virus (KSHV) keep themselves safe from being destroyed.

Adam Cheng studied about these viruses and stated that in some cases they activate and cause cancerous growth. He said that research has further proceeded and now it’s possible to suppress those viruses forever. It can be done through the use of CRISPR/Cas9 gene editing technology.

An opponent of these viruses is a human DNA enzyme called as APOBEC3B which kills EBV and KSHV when they replicate. These viruses oppose the action of APOBEC3B by producing proteins BORF2 and ORF61. Binding takes place between these proteins and human DNA enzyme which inhibits the enzyme from performing its main function.

Though it was a challenge to sort out this issue. If the viral defense proteins are targeted, it could pave way for drug development. Senior Author Reuben Harris also assures this by saying that by blocking the virus defense proteins, it may be possible to prevent the development of the cancers caused by EBV and KSHV. If the viral proteins are eliminated, human DNA enzyme would work in a normal way inhibiting replication of EBV and KSHV.

Gene editing technology will prevent cancer that might occur due to 2 viruses. According to a study, one of these viruses can cause mononucleosis.

When the scientists are performing an experiment, sometimes they don’t have an idea of what they are going to achieve. This discovery is appreciable as it motivates the scientists to work harder and create such effective therapeutic treatments which could save the innocent lives.

https://www.neb.com/tools-and-resources/feature-articles/crispr-cas9-and-targeted-genome-editing-a-new-era-in-molecular-biology

https://www.specialtypharmacytimes.com/news/new-approach-may-halt-development-of-cancer-linked-to-mono

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